Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
Identifieur interne : 001F63 ( Main/Exploration ); précédent : 001F62; suivant : 001F64Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
Auteurs : Shuang Yong Ma [Finlande] ; Matias Röytt [Finlande] ; Juha O. Rinne [Finlande] ; Yrjö Collan [Finlande] ; Urpo K. Rinne [Finlande]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1997.
Abstract
Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P<0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P<0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P<0.001) and with the stage of disease (r=−0.58, P<0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.
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DOI: 10.1016/S0022-510X(97)00100-7
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Rinne</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation><affiliation><wicri:noCountry code="no comma">Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">151</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="87">87</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6</idno><idno type="DOI">10.1016/S0022-510X(97)00100-7</idno><idno type="PII">S0022-510X(97)00100-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P<0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P<0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P<0.001) and with the stage of disease (r=−0.58, P<0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name></region><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K" last="Rinne">Urpo K. Rinne</name><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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